基本情况
姓名：齐雯
性别：女
职称：副教授
所在部门：劳动卫生与环境卫生学教研室
最后学历：研究生
最高学位：博士
电话：0431-85619453
Email: qiwen@jlu.edu.cn
详细情况
研究方向：环境污染物人群健康效应研究
讲授课程：《预防医学》 《环境卫生学》 《环境与健康研究方法与应用》《环境暴露与儿童健康》 《空气理化检验》
教育经历：
2016.08-2019.06，金沙2004路线js5，劳动卫生与环境卫生学，博士，导师 叶 琳
2013.08-2016.06，金沙2004路线js5，劳动卫生与环境卫生学，硕士，导师 齐燕飞
2008.08-2013.06，金沙2004路线js5，预防医学，学士，导师 寇长贵
工作经历：
2019.09至今，金沙2004路线js5
2019.09-2022.09，金沙2004路线js5 博士后 合作导师 金顺子
科研项目：
主持项目：
1. 2023年，吉林省留吉博士后人才计划项目，《ATP7A介导铜稳态失衡在DBDPE所致甲状腺毒性中的作用及其机制研究》
2. 2023年，金沙2004路线js5白求恩计划项目，《线粒体铜稳态失衡介导铜死亡在DBDPE所致甲状腺毒性中的作用机制研究》
作为核心人员参与项目：
1. 2020年，国家自然科学基金面上项目，《基于基因芯片研究雌激素受体作用网络在DEHP甲状腺毒性中的作用及其机制》
2. 2020年，吉林省科技厅科技发展计划项目，《载脂蛋白B100抗体制备及其在冠心病诊疗中的应用》；
3. 2020年，吉林省教育厅项目，《Notch信号通路在增塑剂DEHP所致脂代谢紊乱中的双调控机制》；
学术论文：
1. Qi W, Xu Q, Xu Y, Wang Z, Yang L, Guo S, Shi Y, Zhao T, Zhou L, Ye L. Effect of Notch pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate on 3T3-L1 cells. Ecotoxicol Environ Saf. 2021 Jan 15;208:111472.
2. Ding S#, Qi W#, Xu Q, Zhao T, Li X, Yin J, Zhang R, Huo C, Zhou L, Ye L. Relationships between di-(2-ethylhexyl) phthalate exposure and lipid metabolism in adolescents: Human data and experimental rat model analyses. Environ Pollut. 2021 Oct 1;286:117570.
3. Xu Q, Zhou L, Ri H, Li X, Zhang X, Qi W*, Ye L*. Role of estrogen receptors in thyroid toxicity induced by mono (2-ethylhexyl) phthalate via endoplasmic reticulum stress: An in vitro mechanistic investigation. Environ Toxicol Pharmacol. 2022 Nov;96:104007.
4. Xu Q, Zhang B, Li X, Ye JM, Huo CY, Yin JL, Zhang RX, Zhao WS, Qi W*, Ye L*. Mono-2-ethylhexyl Phthalate Promotes Migration and Invasion by Regulating the Epithelial-Mesenchymal Transition in SH-SY5Y Cells. Biomed Environ Sci. 2022 Mar 20;35(3):276-281.
5. Zhang B, Li X, Zhang X, Ye J, Zhao W, Zhang M, Xing J, Qi W*, Ye L*. Role of Notch pathway in effect of mono-2-ethylhexyl phthalate on the proliferation and cell cycle of SH-SY5Y cell. Environ Toxicol. 2021 Sep;36(9):1944-1952.
6. Qi W, Zhou L, Zhao T, Ding S, Xu Q, Han X, Zhao Y, Song X, Zhao T, Zhang Z, Ye L. Effect of the TYK-2/STAT-3 pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate [J]. Molecular and Cellular Endocrinology. 2019. 484: 52-58.
7. Qi W, Zhang B, Qi Y, Guo S, Tian R, Sun J, Zhao M. The Anti-Proliferation Activity and Mechanism of Action of K12[V18O42(H₂O)]∙6H₂O on Breast Cancer Cell Lines [J]. Molecules. 2017. 22(9):1535.
8. Qi W, Qin Y, Qi Y, Guo L, Li J. In Vitro Antitumor Activity of a Keggin Vanadium-Substituted Polyoxomolybdate and Its ctDNA Binding Properties[J].Journal of Chemistry.2016.753751.
9. Qi W, Li X, Xu Q, Yang L, Guo S, Shi Y, Zhao T, Zhou L, Ye L. Effect of Notch Pathway on Lipid Accumulation Induced by DEHP/MEHP in vitro and in vivo. 2019环境与健康会议. 2019.10.28-2019.10.30.
10. Xu Q, Qi W, Zhang Y, Wang Q, Ding S, Han X, Zhao Y, Song X, Zhao T, Zhou L, Ye L. DNA methylation of JAK3/STAT5/PPARγ regulated the changes of lipid levels induced by di (2-ethylhexyl) phthalate and high-fat diet in adolescent rats. Environ Sci Pollut Res Int. 2020 Aug;27(24):30232-30242.
11. Zhang X, Qi W, Shi Y, Li X, Yin J, Huo C, Zhang R, Zhao W, Ye J, Zhou L, Ye L. Role of miR-145-5p/ CD40 in the inflammation and apoptosis of HUVECs induced by PM2.5. Toxicology. 2021 Dec;464:152993.
12. Zhang X, Qi W, Xu Q, Li X, Zhou L, Ye L. Di(2-ethylhexyl) phthalate (DEHP) and thyroid: biological mechanisms of interference and possible clinical implications. Environ Sci Pollut Res Int. 2022 Jan;29(2):1634-1644.
13. Zhao T, Qi W, Yang P, Yang L, Shi Y, Zhou L, Ye L. Mechanisms of cardiovascular toxicity induced by PM2.5: a review. Environ Sci Pollut Res Int. 2021 Dec;28(46):65033-65051.
14. Yang L, Zhang Y, Qi W, Zhao T, Zhang L, Zhou L, Ye L. Adverse effects of PM2.5 on cardiovascular diseases. Rev Environ Health. 2021 Apr 1;37(1):71-80.
15. Xu Q, Ding S, Qi W, Zhang X, Zhang M, Xing J, Ju A, Zhou L, Ye L. JAK3/STAT5b/PPARγ Pathway Mediates the Association between Di(2-ethylhexyl) Phthalate Exposure and Lipid Metabolic Disorder in Chinese Adolescent Students. Chem Res Toxicol. 2023 May 15;36(5):725-733.
16. Guo S, Zhang B, Qi W, Cao X, Xu Y, Zhang X, Li X, Zhou L, Ye L. Role of estrogen receptor alpha in MEHP-induced proliferation and invasion of SH-SY5Y cells. Toxicology. 2021 Apr 15;453:152734.
获奖情况：2019环境与健康会议优秀展报奖，金沙2004路线js5优秀班主任，金沙2004路线js5教师讲课比赛优秀奖
社会兼职：Ecotoxicology and Environmental Safety、Chemosphere、Biomedical and Environmental Sciences等国际知名期刊受邀审稿人
